Proposal of Dissertation Essay Example | Topics and Well Written Essays - 1000 words

Proposal of Dissertation - Essay Example Though, this particular research is carried out primarily with an academic interest, yet if carried out in an objective manner, research not only helps the researcher in knowing about many unknown aspects, but it often provides a benchmark for future researches as well. Quite often industry too takes a cue from such studies in their policy papers etc. depending upon the objectives and inferences of the study. Research philosophy is a belief about the way in which data about a phenomenon should be gathered, analyzed and used. This dissertation is a more of a qualitative case study focusing on an analysis of the e-business phenomenon in general and analysis of some specific examples. While the concept has proved to be a revolutionary one, there are some concerns as well. During the course of the research an effort would also be made to analyse such concerns. To carry out such a study in general we resort to the following main approaches; In addition to reviewing the existing literature available in the public domain, efforts would also be made to seek opinion of some people involved in e-business operations. This sample group of people would comprise of users, technology service providers, company owners/ managers and some government functionaries or regulators. This will not only help in finding out some primary data, but it will also provide me an opportunity to gain some first-hand information. Whilst this study required participation of human subjects, consent and confidentiality will be a significant issue. If we need to conduct interview or solicit responses to the questionnaire during the course of the research, all possible efforts would be made to communicate the aim and purpose of the study to the participants beforehand. Acquiring informed consent is vital to a researcher. Such a consent document serves as protection both for

Corporate Social Responsibility Essay Example | Topics and Well Written Essays - 2000 words - 3

Corporate Social Responsibility - Essay Example In decades, there have been diverse arguments over the corporate social responsibility (Tricker, 1998). The cases against the CSR concept begin with classical economic argument started by Freidman. Freidman holds that management has only one responsibility of maximizing the profits of the shareholders and the owner (Friedman, 1970). He argues that social issues are not a business concern and that the issues should get resolved by free market system unfettered workings. Additionally, the other argument is that business does not have equipment for handling social activities. On the other hand, the argument in favor of the corporate social resource begins with the belief of business’s long-term enlighten self-interest of being socially responsible. The point of view suggests that in order to have a healthy environment for the business in future, the managers should take action now for long-term viability. Additionally, the other argument is that the responsibility wards off the g overnment regulations (Baron, 2013). Therefore, using different corporate social responsibility concepts, this paper will different corporate social responsibility in the two case studies and provide an ethical analysis in each of them. Facebook definition is the online a social networking service that has its headquarters in California. The chief executive officer of the corporation is Mark Zuckerberg. As Facebook turns out to be more synonymous with experience on networks, its shareholders tend to earn more benefits. Facebook has been successful in gaining a greatest share of individual’s attention and time. The customer’s challenge in the coming years is to have that dominance of attention and time to convert into a bigger share for their wallets. Most of the shares they spend indirectly or directly on advertising (Wong, 2014). Being an international brand, the greatest ethical challenge that the company faces is online privacy. Online privacy relies on the

I need a research proposal that is related to nursing

I need a that is related to nursing - Research Proposal Example 5 series of 2008, setting new policies/standards and increasing Bachelor of Nursing to a 5-year course from its previous 4-year program. Drawing from perceptions of graduates before and after the CHED Memo NO. 5 ( School Years 2005-2010), the strengths and weaknesses of the old curriculum (SY2005-2009) and the new (SY 2009-2010) can be assessed (Simbulan, p.1). The proposed study will gather data on perceptions of CEU College of Nursing graduates, who passed the Nursing board examination, and have been employed as professional nurses in the country or abroad. Their opinions will be drawn not only from their years of education, but the actual application of their knowledge, competence, and commitment to the profession. Evaluation research shall be applied to determine whether the CHED social intervention produced the intended results, using the method of survey and interview of respondents drawn randomly from the list of practicing CEU nursing graduate-professionals. Response variable s consist in the relevance and effectiveness of (a) the required general education subjects (b) theoretical foundation and fundamentals of nursing practice, and (c) apprenticeship program. Survey instruments shall be farmed out and retrieved by way of e-mail or letters through the assistance of the CEU Alumni Foundation. Both qualitative and quantitative analysis shall be done, utilizing survey and open interview data results.

Functions of Enzymes in Metabolic Reaction

Functions of Enzymes in Metabolic Reaction Enzymes have a fundamental role in all metabolic reaction that occurs in all living organisms. Enzymes are proteins which has the ability to bind to substrates and break substrate into products. In most cases, enzymes act as catalyst as they aid the reactants to come closer by using their active sites. In this essay I will be reviewing the structure and function of a serine protease known as subtilisin and I will analyze the different techniques used by different researchers to define the structure or functions of Subtilisin. Subtilisin is found in various forms such as Carlsberg and BNP. All three enzymes are from different origins, however they have similar primary structure although, their tertiary structures are completely different. Subtilisin BPN is an extracellular protease enzyme of a spore forming organism Bacullus Amyloliquelaniens. This enzyme contains a single peptide chain of amino acid containing 275 residues with no disulphide bridges or SH group. The subtilisin BNP contains 8 right handed ÃŽ ± helical segment these regions are (Alden et al, 1970). Many distortion has been observed due to the standard helix. The longest helix contains a number of residues such as Ala 223 to Histidine 238 which runs all the way from the top of the molecule thought the molecules and to the other end. The other 6 helical segments lie approximately parallel to the longest helix (Alden et al, 1970). Subtilisins are example of serine protease these are found in every organism that exists. There are several examples of serine protease enzyme and one of them is alpha-Chymotrypsin which is one of the known enzymes in the Trypsin family. The Trypsin and the subtilisin are believed to have evolved as they have similar mechanism of action even though they are not detectably related. Subtilisin is a bacterial protease, however Trypsin including ÃŽ ±-Chymotrypsin, Trypsin and Elastase re from mammalian origin. These are the known enzymes to have evolved convergent because they have similar active sites and catalytic mechanisms but has no similarities in terms of sequence or conformational homology. The two known types of subtilisin are BNP and Carlsberg; both have similar polypeptide chain, but there are segments on the chain where a number of residues has either been replaced or deleted. According to Emil (1966), BPN consist of peptide chain of 275 amino acids residues, however Carlsber g enzyme contains only 274 amino acid residues. As mentioned in this paper, the chain is only different by 83 residues which may lead to the question why they are different . Furthermore, the similarities and differences between BNP and Carlsberg suggest there have been deletions which have caused both of these enzymes to evolve in different ways. These enzymes are believed to be serine protease enzymes which means they all originate from the same source and due to evolution these enzyme has been converging away from each others path and both enzyme adapted in its environment in order to survive. This resulted subtilisin to be present in bacteria and ÃŽ ±-Chymotrypsin is found in the mammalian pancreas. This now brings us to the point that ÃŽ ±-Chymotrypsin and Subtilisins having the same catalytic mechanisms. This suggest that both Trypsin family and subtilisin family originates from source. Serine proteases are highly specific enzymes as they use His, Ser and Asp part of their active site. The main characteristic of a serine protease is that they have a unique Ser residue of exceptional reactivity that forms a covalent bond with some of the substrates or inhibitors (Creighton J). In both Trypsin and subtilisin shows many similarity and both contains the particularly highly reaction serine residue which can be specifically phosphorylated by other substrate such as isoprophylfluorophosphate (Alden and Wright, 1970), sulphonated and acylated using different enzymes. Further, research was carried out to find out the protonotic equilibria exhibited by both of these enzymes. The enzymatic similarity between the two different serine protease could be the involvement of a Histidine residue as it has been mentioned in most literature. Previous studies suggested that tertiary structure of ÃŽ ±-Chymotrypsin and subtilisin contains hydrogen bonding involvement in the Enzyme-substrate complex (Polgar and Bender, 1969). The Kcat for hydrolysis of p-nitrophenyl acetate by BPN depends on a group with a pK of 7.2, which presumably was Histidine (Alden and Wright, 1970). Studies were carried out to determine the structure of the enzymes by Neidhart et al (1988) and they successfully refined the structure of Carlsberg. The structure was refines at 2.5 Ã… resolution using X-ray crystallography. Wright et all (1969) found out that subtilisin BNP possesses the catalytic triad, arrangement of active site including Aspartate, Histidine, and serine residues characteristic of the Trypsin family. Further study carried out by Robertus et al (1972), demonstrated that the arrangement and characteristics of the active site is identical for both BPN and other member of the Trypsin family, which means the peptide around the active site were highly conserved. In contrast, the overall peptide chain folding of subtilisin BPN reassembles those in the Trypsin family. Thus the relationship between BPN and mammalian Trypsin family of enzymes have been classified as a case of convergent evolution (Robertus et all, 1972). The catalytic triad consist of the residue Asp 32 , His 64 and Ser 221. This supports the charge relay hypothesis and the catalytic triad is the most important part of the serine protease as it helps the enzymes to work effectively. Subtilisin also contains calcium binding loops which contains abut 75-81 residues which is identical in both type of subtilisin (Neidhart et al, 1988). Subtilisin and ÃŽ ± Chymotrypsin both are highly specific as they only bind to specific substrates. For example, proflovin is a good competitive inhibitor for ÃŽ ± Chymotrypsin is inefficient against subtilisin. And oppositely subtilisin has a good competitive inhibitor 4-(4aminophenylaze)-phenylarsonic acid, where as it doesnt interact with Chymotrypsin at all (Alden et al, 1970). Despite the Histidine residue in the active site, some specific inhibitors still bind to the active site by acylation of the Histidine of the Chymotrypsin; however they do not react with subtilisin. There are differences between subtilisin and Trypsin; subtilisin does not contain any disulphide bridges, but Chymotrypsin has five and Trypsin has 6 which suggest that trypsins are more cystine rich. So apart from the surrounding area of the serine 221 in subtilisin, these two classes have no resemblance from each other as far as the primary sequence is concern (Alden et al, 1970).

Comparing Moral Systems in Lord of the Flies, Crime and Punishment, Scarlet Letter, and Pygmalion :: comparison compare contrast essays

Superficial Moral Systems Exposed in William Golding’s Lord of the Flies, Fyodor Dostoyevsky’s Crime and Punishment, Nathaniel Hawthorne’s The Scarlet Letter, and George Bernard Shaw’s Pygmalion    "The superficial nature of human moral systems" is a valid concern in society today. This has always been a factor in society that authors have felt the need to address. People see the hypocrisy in themselves and know that it exists in others. The manners that are so commonly used in public are rarely practiced in private. Most people are ashamed to say and do what they believe is right when they are in public. This understanding causes people to worry what other human beings are doing out of the public view. If it weren't for the opinions of others, most of the popular ideas on morality would not be implemented at all. In The Lord of the Flies, the morality of apparently civilized boys gradually seems to vanish in direct relation to the amount of time that they are separated from society. They never understood why they had behaved themselves before they were stranded on the island. They only repeated the moral systems of their parents just as any other perfunctory gesture. As soon as they are on their own, they begin to do what is easiest rather than what is "proper." This concept is not far from what the reaction to any person would be in this situation. If someone found that suddenly he were not longer responsible to anyone, his life would greatly change from the way it was before. People do many things to please family and friends. People only do what is expected. If moral behavior is no longer expected, it will stop being practiced. A perfect example of this human hypocrisy lies in The Scarlet Letter's Arthur Dimmesdale. To his congregation, Dimmesdale is an icon of morality, but he knows better. Every night he beats himself with a "bloody scourge" because he knows that while he is preaching against adultery, he has committed this act. In his Puritan society, what he has done is not allowed. Not only does he not want to be punished, but he also wants to keep his influence in the community. The public opinion is dear to him. He has convinced himself that it is better for everyone if he does not confess, but he knows that he is lying to himself.